Results of Pilot Study testing GAIM-supported Clinical Imaging Decision Support Systems
Performance Evaluation of AIA3 and CLNQ4 GAIM Systems in Retinal Diagnostics In January 2026, UMSN AI in Health , W.K. Kellogg Eye Center , and SOCR-GAIM conducted a comprehensive evaluation of a pair of advanced clinical decisions support systems Generation-3 Augmented Intelligence Agent (AIA3) , and Generation-4 Clinical Decision Support System (CLNQ4) . AIA3 and CLNQ4 are the latest generations of progressively more advanced foundational and generative artificial intelligence models (GAIMs) , which are designed and trained to understand massive amounts of rich and heterogeneous biomedical information. This pilot study evaluated AIA3 and CLNQ4 , the latest iterations of foundational GAIM systems, on their ability to provide rapid, scalable, and clinically appropriate decision support for medical imaging. The Clinical Challenge . Fundus photography, which documents the retina to monitor disease progression, is a vital tool for ophthalmologists a...